A Phase I Evaluation of Inactivated Influenza A/H5N1 Vaccine Administered by the Intradermal or the Intramuscular Route
Identifieur interne : 001134 ( Main/Exploration ); précédent : 001133; suivant : 001135A Phase I Evaluation of Inactivated Influenza A/H5N1 Vaccine Administered by the Intradermal or the Intramuscular Route
Auteurs : Shital M. Patel [États-Unis] ; Robert L. Atmar [États-Unis] ; Hana El Sahly [États-Unis] ; Thomas R. Cate [États-Unis] ; Wendy A. Keitel [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 2009.
Abstract
In a phase I clinical trial, one hundred healthy young adults were randomized to receive two doses 28 days apart of an inactivated, subvirion vaccine containing 15µg or 45µg of influenza A/H5N1 hemagglutinin (HA) by the intramuscular (IM) route, or 3µg or 9µg of H5 HA by the intradermal(ID) route. Seventy-seven subjects received a third dose. All regimens were safe and well tolerated. Antibody responses after two or three doses were low (≤20% or ≤38%, respectively) and similar in groups given 3µg or 9µg ID or 15µg IM, and were significantly lower than those given 45µg IM. Higher dosages of H5 HA and/or inclusion of adjuvant will be required to enhance immunogenicity by the ID route.
Url:
DOI: 10.1016/j.vaccine.2009.10.152
PubMed: 19931380
PubMed Central: 2913582
Affiliations:
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Keitel</name><affiliation wicri:level="1"><nlm:aff id="A1">Baylor College of Medicine, One Baylor Plaza, MS: BCM280, Houston, Texas 77030, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baylor College of Medicine, One Baylor Plaza, MS: BCM280, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><idno type="eISSN">1873-2518</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">In a phase I clinical trial, one hundred healthy young adults were randomized to receive two doses 28 days apart of an inactivated, subvirion vaccine containing 15µg or 45µg of influenza A/H5N1 hemagglutinin (HA) by the intramuscular (IM) route, or 3µg or 9µg of H5 HA by the intradermal(ID) route. Seventy-seven subjects received a third dose. All regimens were safe and well tolerated. Antibody responses after two or three doses were low (≤20% or ≤38%, respectively) and similar in groups given 3µg or 9µg ID or 15µg IM, and were significantly lower than those given 45µg IM. Higher dosages of H5 HA and/or inclusion of adjuvant will be required to enhance immunogenicity by the ID route.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Patel, Shital M" sort="Patel, Shital M" uniqKey="Patel S" first="Shital M." last="Patel">Shital M. Patel</name></noRegion><name sortKey="Atmar, Robert L" sort="Atmar, Robert L" uniqKey="Atmar R" first="Robert L." last="Atmar">Robert L. Atmar</name><name sortKey="Cate, Thomas R" sort="Cate, Thomas R" uniqKey="Cate T" first="Thomas R." last="Cate">Thomas R. Cate</name><name sortKey="El Sahly, Hana" sort="El Sahly, Hana" uniqKey="El Sahly H" first="Hana" last="El Sahly">Hana El Sahly</name><name sortKey="Keitel, Wendy A" sort="Keitel, Wendy A" uniqKey="Keitel W" first="Wendy A." last="Keitel">Wendy A. Keitel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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